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bad quad when cycling

Dont suppose any also suffers/has suffered from an aching upper quad when cycling. Almost as soon as I get on a bike my left quad feels tired and aches a little. Right one is fine and the bike set up is fine and has been checked a couple of times. I dont feel like I am losing too much power but it is noticable and was hoping some of you may have ideas on the cause and what could be done to sort it out.


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