Old thread, but here's my 2-penneth's worth!
I recently removed the 50/34 compact rings and replaced with single 44t hope narrow wide.
Cranks are FSA Gossamer compacts. mounted the 44T on the back side of the spider, changed the wavy washer from non-drive to drive side.
Change rear cassette from 11-25 to 11-28, both 10-speed. No dropped chains, approximately 130g saved and 10 USABLE gears. No repeated ratios and minimized cross-chaining. Slight reduction of ratios however. But in my case, I am more about high cadence than high gears. so effectively lost the 50:11 and 50:12, which I never used anyway. Also, lost the 34:25 and 24(?) climbing gears. Not a major issue either. Just MTFU'd a bit!
Too many triathletes trying to push hero gears like 53:11. You aren't Tony Martin! Get with the times and spin a bit faster!